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Common use
Sumatriptan is a drug that is used for treating migraine attacks with or without the presence of an aura, to relieve cluster headache attacks. Sumatriptan is a Specific and selective agonist of 5-HT1-serotonin receptors localized mainly in blood vessels of the brain. Migraine headaches are believed to be stipulated by widening of blood vessels in the brain. Sumatriptan causes vasoconstriction of the carotid arterial bed which provides extracranial and intracranial tissues with blood without a significant impact on cerebral blood flow. It also inhibits activity of receptor which are responsible for transmission of pain signals by nerves to the brain.
Dosage and direction
Treatment with Sumatripan should be done just before the starting of a migraine attack. Recommended oral dose of adults is 25-50 mg, the dose maybe increased up to 100 mg if necessary. The medication is effective at any stage of the attack but if it does not help during the attack additional dose should not be taken. Treatment with Sumatriptan should be continued to prevent the next attack. Tablet of Sumatriptan should be swallowed whole, take it with a big glass of water. Usual intranasal dose of 5-20 mg may be increased to the maximum dose of 40 mg daily.

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śro, 30 marzec 2011